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秦峰


职务/职称: 研究员
联系电话: (86)-010-62836875
电子邮件: qinfeng@ibcas.ac.cn
个人网页: http://www.klpmp.net/ktz_display.asp?ktid=50&ktclass=8
课 题 组: 植物抗水分胁迫的分子应答研究组

秦峰,女,博士,研究员,博士生导师。

        1975年10月出生于湖北省武汉市,1998年和2001年在华中农业大学获学士和硕士学位,2004年在清华大学获博士学位。2004年至2010年在日本国际农林水产业研究中心从事博士后研究工作。2010年入选中国科学院“百人计划”,任中国科学院植物研究所研究员。近年来在Plant Cell、Plant Journal、Plant Physiology、PNAS上发表论文数十篇。

主要研究工作:

1.  玉米抗旱基因的克隆和功能分析

    通过对抗旱性的全基因组关联分析,发掘和克隆玉米中重要的抗旱候选基因,利用分子生物学的研究手段和方法,阐明基因在植物体内的功能。同时分析玉米不同转录因子基因家族(AP2/EREBP、bZIP、NAC)中的各成员对抗旱性的贡献,确定玉米中在抵抗干旱胁中最重要的转录因子。研究旨在鉴定和克隆玉米中重要的抗旱性基因,并运用克隆到的基因或分子标记改良玉米抗旱性。

2. RING类型蛋白泛素化E3 连接酶在植物抗逆和发育中的作用

    蛋白泛素化是真核生物蛋白质重要的转录后修饰方式之一,参与调节细胞周期进程、细胞增生与分化,以及信号传导等多种生理过程。植物中很多类型的转录因子也受到泛素化的修饰,如DRIP1&2泛素化E3连接酶能特异识别受干旱和高盐诱导的转录因子DREB2A,并通过控制其在细胞内的稳定性,参与植物水分胁迫的信号传递。我们希望(1)进一步发现特异与DRIP1&2相互作用的蛋白;(2)DRIP1&2在植物抗水分胁迫和生长发育中的功能;(3)玉米中含RING结构域泛素化E3连接酶在抵抗水分胁迫中德的功能。

主持和参加的科研项目:

[1] “玉米抗旱基因的克隆与功能分析”,中国科学院知识创新工程项目,(项目编号:KSCX2-YW-N-097)(2011.01-2013.12),资助金额200万元

[2] “拟南芥泛素化E3连接酶DRIP1及其互作蛋白在响应水分胁迫应答中的分子机理”自然科学基金面上项目,(项目编号:31171163)(2012.1-2015.12)资助金额70万元

研究论文:

  Wang XL#, Wang HW#, Liu SX, Ferjani A, Li JS, Yan JB, Yang XH*, Qin F*. 2016. Genetic variation in ZmVPP1 contributes to drought tolerance in maize seedlings. Nature Genetics, doi:10.1038/ng.3636. (#Co-first author,*Corresponding author) 

  Ding SC, Zhang B, Qin F. 2015. Arabidopsis RZFP34/CHYR1, a ubiquitin E3 ligase, regulates stomatal movement and drought tolerance via snRK2.6-mediated phosphorylation. Plant Cell, 27: 3228-3244. 

  Mao HD, Wang HW, Liu SX, Li ZG, Yang XH, Yan JB, Li JS, Tran L, Qin F. 2015. A transposable element in a NAC gene is associated with drought tolerance in maize seedlings. Nature Communications,  6:8326. 

  Morimoto K, Mizoi J, Qin F, Kim JS, Sato H, Osakabe Y, Shinozaki K and Yamaguchi-Shinozaki K. 2013. Stabilization of Arabidopsis DREB2A Is Required but Not Sufficient for the Induction of Target Genes under Conditions of Stress. PLoS ONE, 8: e80457. 

  Liu SX, Wang XL,Wang HW, Xin HB, Yang XH, Yan JB, Li JS, Tran L, Shinozaki K, Yamaguchi-Shinozaki K and Qin F. 2013. Genome-wide analysis of ZmDREB genes and their association with natural variation in drought tolerance at seedling stage of zea mays L. PLoS Genetics, 9: e1003790. 

  Ma Y, Qin F and Tran L. 2012. Contribution of genomics to gene discovery in plant abiotic stress responses. Molecular Plant, 5: 1176–1178. 

  Qin F, Kodaira K, Maruyama K, Mizoi J, Tran L-S P, Fujita Y, Morimoto K, Shinozaki K, Yamaguchi-Shinozaki K. 2011. SPINDLY, a negative regulator of GA signaling, is involved in the plant abiotic stress response. Plant Physiology, 157: 1900-1913. 

  Qin F, Yamaguchi-Shinozaki K and Shinozaki K. 2011. Achievements and challenges in understanding plant abiotic stress response and tolerance. Plant Cell Physiology, 52: 1569-1582. 

  Kodaira KS, Qin F, Tran LS, Maruyama K, Kidokoro S, Fujita Y, Shinozaki K and Yamaguchi-Shinozaki K. 2011. Arabidopsis C2H2 zinc-finger proteins AZF1 and AZF2 negatively regulate ABA-repressive and auxin-inducible genes under abiotic stress conditions. Plant Physiology, 157: 742-746. 

  Qin F, Sakuma Y, Tran LS , Maruyama K, Kidokoro S, Fujita Y, Fujita M, Umezawa T, Sawano Y, Miyazono K, Tanokura M, Shinozaki K, and Yamaguchi-Shinozaki K. Arabidopsis DREB2A-Interacting Proteins Function as RING E3 Ligases and Negatively Regulate Plant Drought Stress-Responsive Gene Expression. Plant Cell, 2008, 20, 1693-1707.  

  Qin F, Kakimoto M, Sakuma Y, Maruyama K, Osakabe Y, Tran L. P., Shinozaki K and Yamaguchi-Shinozaki K. Regulation and Functional Analysis of ZmDREB2A in Response to Drought and Heat Stresses in Zea mays L. Plant Journal, 2007, 50, 54-69.  

  Qin F, Li J S, Li X H and Corke H.. AFLP and RFLP linkage map in coix. Genetic Resources and Crop Evolution, 2005, 52, 209-214.  

  Qin F, Sakuma Y, Li J, Liu Q, Li YQ, Shinozaki K and Yamaguchi-Shinozaki K. Cloning and functional analysis of a novel DREB1/CBF transcription factor involved in cold-responsive gene expression in Zea mays L. Plant Cell Physiology, 2004, 45, 1042-1052.  

  Jiang YX, Qin F (co-first author), Ma XY, Li YQ, Bai CL and Fang XH. Measuring specific interaction of transcription factor ZmDREB1A with its DNA responsive element at the molecular level. Nucleic Acids Research, 2004, 32(12): e101.  

  Qin F, Li J, Zhang GY, Zhao Jun, Chen SY and Liu Q. Isolation and characterization of a DRE-binding transcription factor from maize. Acta Botanica Sinica, 2003, 45, 331-339.  

  Qin F, Jiang YX, Ma XY, Chen F, Fang XH, Bai CL and Li YQ. Specific Interaction of Transcription Factor and DNA Element Investigated by Atomic Force Microscopy. Chinese Science Bulletin, 2004, 49, 1376-1380.  

  Tran LS, Urao T, Qin F, Maruyam K, Kakimoto T, Shinozaki K, Yamaguchi-Shinozaki K. Functional analysis of AHK1/ATHK1 and cytokinin receptor histidine kinases in response to abscisic acid, drought, and salt stress in Arabidopsis. Proc. Natl. Acad. Sci. USA. 2007, 104, 20623–20628.  

  Sakuma Y, Maruyama K, Qin F, Osakabe Y., Shinozaki K and Yamaguchi-Shinozaki K. Dual function of an Arabidopsis transcription factor DREB2A in water-stress- and heat-stress-responsive gene expression. Proc. Natl. Acad. Sci. USA. 2006,103, 18822-188227. 

  Sakuma Y, Maruyama K, Osakabe, K, Qin F, Seki, M, Shinozaki, K and Yamaguchi-Shinozaki, K. Functional analysis of an Arabidopsis transcription factor, DREB2A, involved in drought-responsive gene expression. Plant Cell, 2006, 18, 1292-1309.  

  Yoshida, T, Sakuma, Y, Todaka, D, Maruyama, K, Qin, F, Mizoi, J, Kidokoro, S, Fujita, Y, Shinozaki, K and Yamaguchi-Shinozaki, K. Functional analysis of an Arabidopsis heat-shock transcription factor HsfA3 in the transcriptional cascade downstream of the DREB2A stress-regulatory system. Biochem. Biophys. Res. Commun.2008, 368, 515-521.  

  Tran LS, Nakashima K, Sakuma Y, Osakabe Y, Qin F, Simpson SD, Maruyama K, Fujita Y, Shinozaki K, Yamaguchi-Shinozaki K. Co-expression of the stress-inducible zinc finger homeodomain ZFHD1 and NAC transcription factors enhances expression of the ERD1 gene in Arabidopsis. Plant Journal, 2007, 49, 46-63. 

著作专著:

[1] Xin HB, Qin F, and Tran LSP. Transcription Factors Involved in Environmental Stress Responses in Plants. Environmental adaptations and stress tolerance of plants in the era of climate change. Edited by Ahmad P. and Prasad M.N.V. (Springer Science+Business Media Ltd.) (English) (in press)

专利:

[1] 刘强,秦峰,陈受宜. 玉米DREB类转录因子及其编码基因与应用:中国,02125373.2. 2002-08-20.

[2] Yamaguchi-Shinozaki K, Kakimoto M, Qin F, Sakuma Y, Maruyama K. Stress-inducible Transcriptional Factor Originating in Corn: Japan, PCT/JP2006/306057, 2006-10-15.


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