姓  名: 李博强
职务/职称: 研究员
联系电话: (86)-010-62836900
电子邮件: bqli@ibcas.ac.cn
个人网页: http://klpr.ibcas.ac.cn/yjdw/yjy/201207/t20120715_612584.html
课 题 组: 果实逆境应答及生物控制技术研究组
李博强,男,博士,研究员,博士生导师。

2000年和2003年在沈阳农业大学获得农学学士和硕士学位,2006年在中科院植物研究所获得理学博士学位,毕业后留所工作至今,2018年晋升为研究员。2015年入选中国科学院青年创新促进会,2017年获国家自然科学基金委优秀青年基金资助,2019年被评为中国科学院青年创新促进会优秀会员,同年获得中国植物病理学会青年植物病理学家奖。现任中国植物病理学会产后病理学专业委员会副主任、中国园艺学会采后科学技术分会副秘书长,曾任中国科学院青年创新促进会秘书长(2019-2021)。

主持国家自然科学基金委优秀青年基金1项,面上项目3项,青年基金1项,国家重点研发计划课题1项、子课题2项,中科院重点部署项目课题1项。发表论文90余篇,累计引用3000余次。其中,以通讯作者和第一作者(含并列)在Comprehensive Reviews in Food Science and Food SafetyNew PhytologistFood ChemistryEnvironmental MicrobiologyPostharvest Biology and TechnologyMolecular Plant-Microbe Interaction等期刊发表SCI论文24篇;获得省部级奖励7项;获得授权国家发明专利13项。担任Postharvest Biology and TechnologyBiological ControlHorticulturae、未来食品科学、微生物学报等学术期刊的编委及科技智库期刊《中国科学院院刊》首届青年编委

主要研究方向和内容:

1)果实采后病害发生的分子机制及控制技术

以青霉病等果实采后主要病害为研究对象,揭示微生物组、寄主和环境之间互作的分子网络,鉴定调控病原菌致病力和寄主抗病性的关键因子;筛选高活性靶向抑菌物质,研发采后病害新型控制技术和产品。

2)真菌毒素生物合成的分子基础及污染控制技术

以棒曲霉素等果蔬产品重要真菌毒素为研究对象,解析真菌毒素生物合成和转运的分子途径,鉴定影响真菌毒素合成的内、外源关键因子,建立分子调控网络;筛选降解真菌毒素的微生物菌株,鉴定高效降解真菌毒素的生物酶;通过定向进化、分子改造等方法提升降解效率,研制商业化应用的真菌毒素降解酶制剂。

主持和参加的科研项目:

1)     生鲜农产品产后供应链品质与环境关联机制,十四五国家重点研发计划课题(2021YFD21005012021.12-2026.11),主持人。

2)     组蛋白甲基化修饰调控扩展青霉棒曲霉素生物合成的分子机制,国家自然科学基金面上项目(320722732021.01-2024.12),主持人。

3)     中国科学院青年创新促进会优秀会员,中国科学院人才项目(Y2019192020.01-2022.12),主持人。

4)     植物源食品采后生物学基础,国家自然科学基金优秀青年基金(317220432018.01-2020.12),主持人。

5)     高值特色果蔬冷链物流及包装技术研发示范——猕猴桃物流防腐保鲜技术研发和示范,十三五国家重点研发计划子任务(2018YFD0401303-22018.07-2020.12),主持人。

6)     果蔬采后质量与品质控制关键技术研究及装备开发——病原真菌毒素合成的分子基础和转运途径研究,十三五国家重点研发计划子任务(2016YFD04009022016.07-2020.12),主持人。

7)     果实采后病原真菌分泌组的N-糖基化修饰分析和调控机制研究,国家自然科学基金面上项目(313718632014.01-2017.12),主持人。

8)     高值特色果实采后品质安全的防控技术,中科院重点部署项目课题,(KFZD-SW-102-52016.01-2016.12),主持人。

9)     中国科学院青年创新促进会,中科院人才项目(20150632015.10-2018.12),主持人。

10)  环境pH对果实采后病原真菌致病力的影响和调控机制研究,国家自然科学基金面上项目(311717652012.01-2015.12),主持人。

11)  酵母拮抗菌与果实采后病原真菌细胞间的互作机制研究,国家自然科学基金青年基金(307005532008.01-2010.12),主持人。

研究论文(#同等贡献;*通讯作者)

2022

Chen YZhang ZQTian SPLi BQ*. 2022. Application of -omic technologies in postharvest pathology: Recent advances and perspectives. Current Opinion in Food Science. 45:100820.

Xing, MY, Chen Y, Li BQ*, Tian SP*. 2022. Highly efficient removal of patulin using immobilized enzymes of Pseudomonas aeruginosa TF-06 entrapped in calcium alginate beads. Food Chemistry. 377, 131793.   

Zhuo RL, Li BQ*, Tian SP. 2022. Alginate oligosaccharide improves resistance to postharvest decay and quality in kiwifruit (Actinidia deliciosa cv. Bruno). Horticultural Plant Journal. 8, 44-52.

Li BQ, Chen Y, Tian SP*. 2022. Function of pH-dependent transcription factor PacC in regulating development, pathogenicity, and mycotoxin biosynthesis of phytopathogenic fungi. The FEBS Journal. 289, 1723-1730.

2021

Xing MY, Chen Y, Li BQ*, Tian SP*. 2021. Characterization of a short-chain dehydrogenase/reductase and its function in patulin biodegradation in apple juice. Food Chemistry. 348, 129046.

Chen Y, Zhang ZQ, Li BQ*, Tian SP*. 2021. PeMetR-mediated sulfur assimilation is essential for virulence and patulin biosynthesis in Penicillium expansum. Environmental Microbiology. 23, 5555-5568.

Xia YX, Zhuo RL, Li BQ*, Tian SP. 2021. Effects of 1-methylcyclopropene on disease resistance of red-fleshed kiwifruit during long-term cold storage and the possible mechanisms. New Zealand Journal of Crop and Horticultural Science. 49, 182-195.

2020

Li BQ#, Chen Y#, Zhang ZQ, Qin GZ, Chen T, Tian SP*. 2020. Molecular basis and regulation of pathogenicity and patulin biosynthesis in Penicillium expansum. Comprehensive Reviews in Food Science and Food Safety. 19, 3416-3438.

Xing MY#, Li BQ#, Chen Y, Tian SP*. 2020. Ribonucleoside diphosphate reductase plays an important role in patulin degradation by Enterobacter cloacae subsp. dissolvens. Journal of Agricultural and Food Chemistry. 68, 5232-5240.

Zhang XK#, Li BQ#, Zhang ZQ, Chen Y, Tian SP*. 2020. Antagonistic yeast: a promising alternative to chemical fungicides for controlling postharvest diseases of fruit. Journal of Fungi. 6, 158.

2019

Li BQ#, Chen Y#, Zong YY#, Shang YJ, Zhang ZQ, Xu XD, Wang X, Long MY, Tian SP*. 2019. Dissection of patulin biosynthesis, spatial control and regulation mechanism in Penicillium expansum. Environmental Microbiology. 21: 1124-1139.

2018

Chen Y#. Li BQ#, Xu XD, Zhang ZQ, Tian SP*. 2018. The pH-responsive PacC transcription factor plays pivotal roles in virulence and patulin biosynthesis in Penicillium expansum. Environmental Microbiology. 20: 4063-4078.

郑剑, 蒋镇烨, 戚雯烨, 潘洁, 郑小林*, 李博强*. 2018. 伞形花内酯处理对美味猕猴桃果实品质和青霉病抗性的影响. 园艺学报. 45(04): 734-742.

王晓, 徐晓迪, 陈勇, 卓瑞玲, 田世平, 李博强*. 2018. 宁夏枸杞鲜果采后病原菌的分离、鉴定及水杨酸的抑病效果研究. 食品安全质量检测学报. 9(22): 5837-5842.

2017

Chen Y, Peng HM, Wang X, Li BQ*, Long MY, Tian SP. 2017. Biodegradation mechanisms of patulin in Candida guilliermondii: an iTRAQ-based proteomic analysis. Toxins. 9: E48.

Li BQ, Xia YX, Wang YY, Qin GZ, Tian SP*. 2017. Characterization of genes encoding key enzymes involved in anthocyanin metabolism of kiwifruit during storage period. Frontiers in Plant Science. 8:341.

李博强,陈 勇,徐小迪,王晓,田世平*. 2017. 棒曲霉素的生物合成、调控机制及其控制技术研究进展. 食品安全质量检测学报. 8(9): 3283-3288.

2016

An B#, Li BQ#, Li H, Zhang ZQ, Qin GZ, Tian SP*. 2016. Aquaporin8 regulates cellular development and reactive oxygen species production, a critical component of virulence in Botrytis cinerea. New Phytologist. 209: 1668-1680.

Li BQ, Peng HM, Tian SP*. 2016. Attachment capability of antagonistic yeast Rhodotorula glutinis to Botrytis cinerea contributes to biocontrol efficacy. Frontiers in Microbiology. 7:601.

2015

Li BQ#, Zong YY#, Du ZL, Chen Y, Zhang ZQ, Qin GZ, Zhao WM, Tian SP*. 2015. Genomic characterization reveals insights into patulin biosynthesis and pathogenicity in Penicillium species. Molecular Plant–Microbe Interactions. 28: 635-647.(封面文章)

2014及以前

Li BQ, Wang WH, Zong YY, Qin GZ, Tian SP*. 2012. Exploring pathogenic mechanisms of Botrytis cinerea secretome under different ambient pH based on comparative proteomic analysis. Journal of Proteome Research. 11: 4249-4260.

Li BQ#, Zhang CF#, Cao BH, Qin GZ, Wang WH, Tian SP*. 2012. Brassinolide enhances cold stress tolerance of fruit by regulating plasma membrane proteins and lipids. Amino acids. 43: 2469-2480.

Shi XQ#, Li BQ#, Qin GZ, Tian SP*. 2012. Mechanism of antifungal action of borate against Colletotrichum gloeosporioides related to mitochondrial degradation in spores. Postharvest Biology and Technology. 67: 138-143.

Li BQ#, Lai TF#, Qin GZ, Tian SP*. 2010. mbient pH stress inhibits spore germination of Penicillium expansum by impairing protein synthesis and folding: a proteomic-based study. Journal of Proteome Research. 9: 298-307.

Li BQ, Zhou ZW, Tian SP*. 2008. Combined effects of endo- and exogenous trehalose on stress tolerance and biocontrol efficacy of two antagonistic yeasts. Biological Control. 46: 187-193.

Li BQ, Tian SP*. 2007. Effect of intracellular trehalose in Cryptococcus laurentii and exogenous lyoprotectants on its viability and biocontrol efficacy on Penicillium expansum in apple fruit. Letters in Applied Microbiology. 44: 437-442.

Li BQ, Tian SP*. 2006. Effects of trehalose on stress tolerance and biocontrol efficacy of Cryptococcus laurentii. Journal of Applied Microbiology. 100: 854-861.