网站地图 | 联系我们 | 管理系统 | 登录邮箱 | 内网办公 | English | 中国科学院    
首页 所况介绍 机构设置 科研成果 研究队伍 合作交流 研究生教育 党群园地 科学传播
 
 
 当前位置:首页 >>> 论文库

Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives

作 者:Wu Q, Han TS, Chen X, Chen JF, Zou YP, Li ZW, Xu YC, Guo YL*
影响因子: 11.908
刊物名称: Genome Biology
出版年份: 2017
卷: 18  期:    页码: 217

文章摘要 : 

Background

In contrast to positive selection, which reduces genetic variation by fixing beneficial alleles, balancing selection maintains genetic variation within a population or species and plays crucial roles in adaptation in diverse organisms. However, which genes, genome-wide, are under balancing selection and the extent to which these genes are involved in adaptation are largely unknown.

Results

We performed a genome-wide scan for genes under balancing selection across two plant species, Arabidopsis thaliana and its relative Capsella rubella, which diverged about 8 million generations ago. Among hundreds of genes with shared coding-region polymorphisms, we find evidence for long-term balancing selection in five genes: AT1G35220, AT2G16570, AT4G29360, AT5G38460, and AT5G44000. These genes are involved in the response to biotic and abiotic stress and other fundamental biochemical processes. More intriguingly, for these genes, we detected significant ecological diversification between the two haplotype groups, suggesting that balancing selection has been very important for adaptation.

Conclusions

Our results indicate that beyond the well-known S-locus genes and resistance genes, many loci are under balancing selection. These genes are mostly correlated with resistance to stress or other fundamental functions and likely play a more important role in adaptation to diverse habitats than previously thought.


| 本站导航 | 园区风光| 联系我们 |
版权所有:中国科学院植物研究所 地址:北京市海淀区香山南辛村20号 邮编:100093 电话:010-62590835
网站备案号:京ICP备05002828号       文保网安备案号:1101080078