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The central circadian clock proteins CCA1 and LHY regulate iron homeostasis in Arabidopsis

作 者:Xu G, Jiang ZM, Wang HY, Lin RC*
影响因子: 3.092
刊物名称: Journal of Integrative Plant Biology
出版年份: 2019
卷: 61  期: 2   页码: 168-181

文章摘要 : 

Circadian clock is the endogenous timekeeping machinery that synchronizes an organism's metabolism, behavior, and physiology to the daily lightdark circles, thereby contributing to organismal fitness. Iron (Fe) is an essential micronutrient for all organisms and it plays important roles in diverse processes of plant growth and development. Here, we show that, in Arabidopsis thaliana, loss of the central clock genes, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), results in both reduced Fe uptake and photosynthetic efficiency, whereas CCA1 overexpression confers the opposite effects. We show that root Fe(III) reduction activity, and expression of FERRIC REDUCTION OXIDASE 2 (FRO2) and IRONREGULATED TRANSPORTER 1 (IRT1) exhibit circadian oscillations, which are disrupted in the cca1 lhy double mutant. Furthermore, CCA1 directly binds to the specific regulatory regions of multiple Fe homeostasis genes and activates their expression. Thus, this study established that, in plants, CCA1 and LHY function as master regulators that maintain cyclic Fe homeostasis.


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