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刘春明


职务/职称: 研究员
联系电话: (86)-010-62836663
电子邮件: cmliu@ibcas.ac.cn
个人网页: http://www.klpmp.net/ktz_display.asp?ktid=39&ktclass=7
课 题 组: 胚胎胚乳发育研究组

刘春明,男,博士,研究员,博士生导师。

  1984年山东师范学院生物系获学士学位;1987年在中国科学院上海植物生理研究所获硕士学位;1996年英国John Innes Centre/UEA获博士学位。1990-1992年在新加坡国立大学做访问研究;1996-1999年在美国OSU从事博士后研究;1999-2005年在荷兰国际植物研究中心担任实验室主任/高级研究员。2006年获得"国家杰出青年基金"和中国科学院"百人计划"择优支持。现任国家重大研究计划首席科学家、中国科学院植物研究所植物分子生理学重点实验室主任、中国细胞学会副监事长、中国作物学会常务理事、Journal of Integrative Plant Biology (JIPB)主编、Plant Molecular Biology Reporter副主编。迄今为止已发表论文70余篇,总引用 3200余次。Plant CellPlant PhysiologyPlant Journal等杂志先后6次将其研究工作作为封面刊登。 

研究方向:

  本研究组致力于探索植物种子(胚胎和胚乳)的发育生物学基础,研究合子胚受精激活的分子机理以及小分子多肽在植物干细胞调控过程中的作用。主要学术贡献包括提出了生长素的极性运输控制植物器官原基形成的理论;建立了植物界第一个细胞质分裂的突变体模型;阐明了控制胚乳细胞分裂所必需的一系列基因;发现AMP脱氨酶在受精卵激活过程中的关键作用;证实了控制干细胞分化的CLV3CLE19基因是以小分子多肽激素形式参与信号传递。研究内容包括:1)受精后合子激活的分子机理;2)胚乳糊粉层和淀粉胚乳分化;3)多肽激素与植物的信号转导;4)水稻TILLING技术平台建设。 

主持和参加的科研项目:

1.重大研究计划:植物胚胎及种子发育的机理研究(2014CB943400),首席科学家;2014.12018.8;资助强度:300/5 

2.国家杰出青年科学基金:植物早期胚胎发育及多肽信号转导,2007.1-2010.12;课题负责人:资助强度:200万元;项目批准号:30625018  

3.重大研究计划:蛋白质功能的代谢与多肽组学研究,首席科学家; 200612-2011.8,资助强度331/五年;项目批准号:2006CB910600 

4.中国科学院百人计划择优支持:课题负责人:2006.10-2009.12;资助强度:200万元; 

5.欧盟第六框架研究计划:development of drought resistant cereals to support efficient water use in the Mediterranean area, 项目负责人; 2006.1-2008.12.31;资助强度:200000 EURO;项目批准号:015468 

研究论文(注*为通讯作者): 

  2016 

  Guo L*, Jiang L*, Zhang Y, Lu XL, Xie Q, Weijers D, Liu CM. 2016. The anaphase promoting complex initiates zygote division in Arabidopsis through degradation of cyclin B1. Plant Journal, 86: 161-174. (*Co-first author) 

  Bai AN, Lu XD, Li DQ, Liu JX, Liu CM. 2016. NF-YB1-regulated expression of sucrose transporters in aleurone facilitates sugar loading to rice endosperm. Cell Research, 26: 384-388. 

  2015 

  Guo L, Liu CM*. 2015. A single-nucleotide exon found in Arabidopsis. Scientific Reports, 5: 18087. 

  Wu X, Liu J, Li D, Liu CM*. 2015. Rice caryopsis development: Dynamic changes in different cell layers. Journal of Integrative Plant Biology, doi: 10.1111/jipb.12440. 

  Bai AN, Lu XD, Li DQ, Liu JX, Liu CM*. 2015. NF-YB1-regulated expression of sucrose transporters in aleurone facilitates sugar loading to rice endosperm. Cell Research, DOI: 10.1038/cr.2015.116. 

  Xu TT, Ren SC, Song XF, Liu CM*. 2015. CLE19 expressed in the embryo regulates both cotyledon establishment and endosperm development in Arabidopsis. Journal of Experimental Botany, 66: 5217-5227. 

  Liu CM*. 2015. Auxin binding protein 1 (ABP1): A matter of fact. Journal of Integrative Plant Biology, 57: 234-235. 

  2014 

  Yan SJ, Liang YT, Zhang JD, Chen Z, Liu CM*. 2014. Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species. Fungal Genetics and Biology, 81: 229-237. 

  Lu X, Zhang D, Li S, Su Y, Liang Q, Meng H, Shen S, Fan Y, Liu CM, Zhang C. 2014. FtsHi4 is essential for embryogenesis due to its influence on chloroplast development in Arabidopsis. PLoS ONE, 9: e99741. 

  Zhang Z, Song Y, Liu CM, Thomma B. 2014. Mutational analysis of the Ve1 immune receptor that mediates verticillium resistance in tomato. PloS ONE, 9: e99511. 

  Zhang JD, Han LD, Yan SJ, Liu CM*. 2014. The non-metabolizable glucose analog D-glucal inhibits aflatoxin biosynthesis and promotes kojic acid production in Aspergillus flavus. BMC Microbiology, 14: 95-104. 

  2013年 

  Xu TT, Song XF, Ren SC, Liu CM* (2013) The sequence flanking the N-terminus of the CLV3 peptide is critical for its cleavage and activity in stem cell regulation in Arabidopsis. BMC Plant Biology, 13:225, doi:10.1186/1471-2229-13-225  

  Xiu-Fen Song, Ting-Ting Xu, Shi-Chao Ren, and Chun-Ming Liu* (2013) Individual amino acid residues in CLV3 peptide contribute to its stability in vitro. Plant Signal Behav, 8: e25344 

  Li S, Chen M. Yu D, Ren S, Sun S, Liu L, Ketelaar, T, Emons AM and Liu CM* (2013) EXO70A1-mediated vesicle trafficking is critical for tracheary element development in Arabidopsis. Plant Cell, 25: 1774-1786 

  Song XF, Guo P, Ren SC, Xu TT, Liu CM*. 2013. Antagonistic peptide technology for functional dissection of CLE genes in Arabidopsis. Plant Physiology, 161, 1076-1085  

  Jiang GQ, Yao XF and Liu CM*. 2013. A simple CELI endonuclease-based protocol for genotyping both SNPs and InDels. Plant Molecular Biology Reporter, 1325-1335 

  Zhang Z, van Esse HP, van Damme M, Fradin EF, Liu C-M, Thomma BPHJ* (2013). Ve1-mediated resistance against Verticillium does not involve a hypersensitive response in Arabidopsis. Molecular Plant Pathology 14: 719–727. 

  Zhang Y, Immink R, Liu CM, Emons A and Ketelaar T* 2013.The Arabidopsis exocyst subunit SEC3A is essential for embryo development and accumulates in transient puncta at the plasma membrane. New Phytologist, 199:74-88. 

  Chu H, Liang W, Li J, Hong F, Wu Y, Wang L, Wang J, Wu P, Liu C, Zhang Q, Xu J, Zhang D* (2013) A CLE-WOX signalling module regulates root meristem maintenance and vascular tissue development in rice. J Exp Bot. 64:5359-5369. 

  Ronny Brandt, Yakun Xie, Thomas Musielak, Moritz Graeff, York-Dieter Stierhof, Hai Huang, Chun-Ming Liu, Stephan Wenkel*  (2013) Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops, Mech. Dev., 130: 25-33. 

  Zhang Z, Fradin E, Jonge R, Esse H.P, Smit P, Liu CM and Thomma B* 2013. Optimized agroinfiltration and virus-induced gene silencing to study ve1-mediated Verticillium resistance in tobacco. Molecular Plant-Microbe Interactions, 26(2): 182-191  

  2012年 

  Song XF, Yu DL, Xu TT, Ren SC, Guo P, Liu CM* 2012, Contributions of individual amino acid residues to the endogenous CLV3 function in shoot apical meristem maintenance in Arabidopsis. Molecular Plant, 5(2):515-523 

  Zhang S, Haider I, Kohlen W, Jiang L, Bouwmeester H, Meijer AH, Schluepmann H, Liu CM*, Ouwerkerk PB*. (2012) Function of the HD-Zip I gene Oshox22 in ABA-mediated drought and salt tolerances in rice. Plant Mol Biol. 2012 80:571–585  

  Dali Yu, Li Jiang, Huaqin Gong, Chun-Ming Liu* (2012) EMBRYONIC FACTOR 19 encodes a PPR protein that is essential for the initiation of zygotic embryogenesis in Arabidopsis. J. Integr. Plant Biol. 54(1):55-64 

  Shijuan Yan, Yating Liang, Jindan Zhang and Chun-Ming Liu* (2012) Aspergillus flavus grown in peptone as the carbon source exhibits spore density- and peptone concentration-dependent aflatoxin biosynthesis. BMC Microbiology, 12:106 

  Wang ZZ, Yan SJ, Liu CM, Chen F and Wang T* 2012. Proteomic Analysis reveals an aflatoxin-triggered immune response in cotyledons of Arachis hypogaea infected with Aspergillus flavus. Journal of Proteome Research, 11, 2739−2753 

  Zheng Y, Xin H, Lin J, Liu CM and Huang SJ* 2012. An Arabidopsis class II Formin, AtFH19, nucleates actin assembly, binds to the barbed end of actin filaments and antagonizes the effect of AtFH1 on actin dynamics. Journal of Integrative Plant Biology, 54(10): 800-813   

  2011年 

  Zheng LY, Guo XS, He B, Sun LJ, Peng Y, Dong SS, Liu TF, Jiang S, Ramachandran S, Liu CM, Jing HC* (2011) Genome-wide patterns of genetic variation in sweet and grain sorghum (Sorghum bicolor). Genome Biol. 12(11):R114. 

  Ma J, Hanssen M, Lundgren K, Hernandez H, Delatte T, Ehlert A, Liu CM, Schluepmann H, Droge-Laser H, Moritz T, Smeekens S and Hanson J* (2011) The sucrose-regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism. New Phytol., 191(3):733-745. 

  2010年 

  Li S, Os G van, Ren S, Yu D, Ketelaar T, Emons A and Liu CM* Expression and functional analyses of EXO70 genes in Arabidopsis implicate their roles in regulating cell type-specific exocytosis. Plant Physiology 2010, 154: 1819-1830  

  Liu CM*, Hu Y (2010) Plant stem cells and their regulations in shoot apical meristems. Fronti. Biol. 5: 417-423 

  Xiufen Song, Peng Guo, Chen Li, Chun-Ming Liu* (2010) The cysteine pairs in CLV2 are not necessary for sensing the CLV3 peptide in shoot and root meristems. J Integr Plant Biol. 52:774-781 

  Zhou W, Wei L, Xu J, Zhai QZ, Jiang HL, Chen R, Chen Q, Sun JQ, Chu JF, Zhu LH, Liu CM and Li CY* (2010) Arabidopsis tyrosylprotein sulfotransferase acts in the Auxin/PLETHORA pathway in regulating postembryonic maintenance of the root stem cell niche. Plant Cell. 22:3692-3709.  

  Yingfang Zhu, Yuqing Wang, Ruili Li, Xiufen Song, Qinli Wang, Shanjin Huang,Jing Bo Jin, Chun-Ming Liu and Jinxing Lin* (2010) Analysis of interactions among the CLAVATA3 receptors reveals a direct interaction between CLAVATA2 and CORY in Arabidopsis. Plant J. 61:223-233. 

  2009年 

  Qinli Wang, Bo Chen, Peng Liu, Maozhong Zheng, Yuqing Wang, Sujuan Cui, Daye Sun, Xiaohong Fang, Chun-Ming Liu, William J. Lucas, and Jinxing Lin* (2009) Calmodulin Binds to Extracellular Sites on the Plasma Membrane of Plant Cells and Elicits a Rise in Intracellular Calcium Concentration. J Biol Chem. 284:12000-12007. 

  Emilie F. Fradin, Zhao Zhang, Juan C. Juarez Ayala, Christian D.M. Castroverde, Ross N. Nazar, Jane Robb, Chun-Ming Liu, and Bart P.H.J. Thomma* (2009) Genetic Dissection of Verticillium Wilt Resistance Mediated by Tomato Ve11. Plant Physiol. 150:320–332. 

  2008年 

  Yong-Feng Fan, Li Jiang, Hua-Qin Gong and Chun-Ming Liu* (2008) Sexual Reproduction in Higher Plants I: Fertilization and the Initiation of Zygotic Program. J Integr Plant Biol. 50:860-867 

  Wang G, Ellendorff U, Kemp B, Mansfield JW, Forsyth A, Mitchell K, Bastas K, Liu CM, Woods-Tor A, Zipfel C, de Wit PJGM, Jones JDG, Tor M, and Thomma BPHJ*2008A genome-wide functional investigation into the roles s of receptor-like proteins in Arabidopsis. Plant Physiology, 147:503-517. 

  2007 

  Fiers M, Ku KL, Liu CM* (2007) CLE peptide ligands and their roles in establishing meristems. Current Opinion of Plant Biology. 10:39-43  

  Ribarits A, Mamun A. N. K., Li S., Resch T., Fiers M., Heberle-Bors E., Liu CM and Touraev A*2007Combination of reversible male sterility and doubled haploid production by targeted inactivation of cytoplasmic glutamine synthetase in developing anthers and pollen. Plant Biotechnology Journal. 2007, 5: 483–494. 

  2006年 

  Fiers M, Golemiec E, van der Schors R, van der Geest L, Li KW, Stiekema WJ, Liu CM* (2006) The CLV3/ESR motif of CLV3 is functionally independent from the non-conserved flanking sequences. Plant Physiology, 141,1284-1294 (cover story,  

  2005年 

  M. Fiers, E. Golemiec, J. Xu, L. van der Geest, R. Heidstra, W. Stiekema, and C.M. Liu* (2005) The 14-Amino Acid CLV3, CLE19 and CLE40 Peptides Trigger Consumption of the Root Meristem in Arabidopsis through a CLAVATA2-Dependent Pathway. Plant Cell 17: 2542-2553 (cover story) 

  J. Xu, H.Y. Zhang, C.H. Xie, H.W. Xue, P. Dijkhuis, and C.M. Liu* (2005) EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis. Plant J. 42:743-756 

  2004年 

  M. Fiers, G. Hause, K. Boutilier, E. Casamitjana-Marinez, D. Weijers, R. Offringa, L. van der Geest, M. van Lookeren Campagne, C.M. Liu* (2004) Mis-expression of the CLV3/ESR-like gene  CLE19 in Arabidopsis leads to a consumption of root meristem. Gene, 327: 37-49 

  2003年 

  E. Casamitjana-Martínez, H. F. Hofhuis, J. Xu, C.M. Liu, R. Heidstra and B. Scheres* (2003) Root-Specific CLE19 Overexpression and the sol1/2: Suppressors Implicate a CLV-like Pathway in the Control of Arabidopsis Root Meristem. Current Biology, 13: 1435-1441. 

  2002年 

  C.M. Liu, John McElver, Irris Tzafrir, Ronny Joosen, Peter Wittich, David Patton, Andre A.M. van Lammeren and David Meinke* (2002) Condensin and cohesin knockouts in Arabidopsis exhibit a titan seed phenotype. Plant J., 29:405-415. 

  K. Boutilier*, R. Offringa, V.K. Sharma,  H.Kieft, T. Ouellet, L. Zhang, J. Hattori, C.M. Liu, A.A. Van Lammeren,  B.L. Miki, J.B. Custers, M.M. Van Lookeren Campagne (2002) Ectopic expression of BABY BOOM triggers a conversion from vegetative to embryonic growth. Plant Cell. 14, 1737-1749. 

  ris Tzafrir, John A. McElver, Chun-ming Liu, Li Jun Yang, Jia Qian Wu, Audrey Martinez, David A. Patton, and David W. Meinke* (2002) Diversity of TITAN Functions in Arabidopsis Seed Development. Plant Physiology 128:32-51. 

  2000年 

  McElver, J., Patton, D., Rambaugh M., Liu C.M. Yang, L.J. and Meinke D* (2000) The TITAN5 gene of arabidopsis encodes a protein related to the ADP ribosylation factor family of GTP binding proteins. Plant Cell 12: 1379-1302. 

  Cordewener, J*, Bergervoet, J. and Liu, C.M. (2000) Changes in protein systhesis and phosphorylation during microspore embryogenesis in Brassica napus. J. Plant Physiol. 156: 156-163. 

  1999年 

  Liu, C.M., Johnson, S. Di Gregorio, S. and Wang, T.L* (1999) single cotyledon (sic) mutants of pea and their relevance to the pattern formation and the evolution of monocots. Developmental Genetics, 25:11-22. 

  1998年 

  Liu, C.M. and Meinke, D.W* (1998) The titan mutants of Arabidopsis are disrupted in mitosis and cell cycle control during seed development. Plant Journal, 16:21-31.  

  1996年 

  Hong Y., Takano, M., Liu, C.M., Gasch, A., Chye, M.L. and Chua, N.-H* (1996) Expression of the three members of the calcium-dependent protein kinase gene family in Arabidopsis thaliana. Plant Molecular Biology, 30: 1259-1275. 

  1995年 

  Liu C.M., Johnson, S. and Wang, T.L* (1995) cyd, a mutant of pea that alters embryo morphology is defective in cytokinesis. Developmental Genetics, 16:312-331. 

  1994年 

  Liu, C.M. Xu, Z.H. and Chua, N.-H* (1994) In vitro culture of Brassica juncea zygotic embryo, in "Plant Tissue Culture Manual: Fundamentals and Applications" K. Lindsey, Ed. Kluwar Academic Publishers, E5, pp1-19. 

  1993年 

  Liu C.M., Z.H. Xu, Z.H. and Chua, N-H* (1993) Proembryo culture: in vitro development of early globular-staged zygotic embryos of Brassica juncea. Plant Journal, 3: 291-300. 

  Liu, C.M., Xu, Z.H. and Chua, N-H* (1993) Auxin polar transport is essential for the establishment of bilateral symmetry during early plant embryogenesis. Plant Cell, 5: 621-630.

 著作专著:

许智宏,刘春明主编,1998。植物发育的分子机理。北京:科学出版社。


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