姓  名: 种康
职务/职称: 研究员
联系电话: (86)-010-62836517
电子邮件: chongk@ibcas.ac.cn
个人网页: http://kclab.ibcas.ac.cn
课 题 组: 植物分子发育生理研究组
种康,男,博士,研究员/教授,博士生导师;中国科学院院士。

中国科学院院士,植物分子发育生理研究组组长、NSFC国家杰出青年获得者、NSFC“细胞分化与器官发生创新群体首席科学家、百千万人才工程国家级人选。中国科学院大学教授。社会兼职有中国植物学会理事长和植物生理与分子生物学会理事。担任Journal of Integrative Plant Biology主编,Journal of Biological ChemistryMolecular Genetics and GenomicsJournal of Genetics and Genomics编委。主持承担多项国家重大项目,如国家战略性先导专项项目、973863项目等。在CellAnnual Review of Plant BiologyNature PlantsNature CommunicationsEMBO JournalPNASGenome BiologyThe Plant Cell等学术期刊发表研究论文80余篇。多次获得中国科学院优秀教师奖励。已培养硕士和博士40余名和博士后5名,其中多名博士生获得中国科学院优秀博士论文奖励和中国科学院院长优秀奖。毕业生中有24名在国外从事博士后研究或工作,其中在美国和国内教授职位5名。 

主要研究工作:

1. 小麦开花与春化作用分子机理

发现植物感知春化信号机制,阐明春化过程中,类凝集素VER2的磷酸化修饰与RNA结合蛋白GRP2的糖基化修饰控制春化基因VRN1RNA剪切介导开花的分子网络机制。

2. 水稻感受低温信号的分子应答机制

发现水稻低温感受复合物及其作用机制,揭示了水稻在人工驯化过程中,耐寒性关键基因起源于中国野生稻。

3. 水稻激素信号互作调控器官发生的分子网络 

揭示植物激素独脚金内酯和甾醇类激素控制水稻侧芽分化与叶角控制的基因网络新机制。 

主持和参加的科研项目:

[1] “创建生态草牧业科技体系”,中国科学院A类先导专项(2019.11-2024.10);专项首席种康

[2] 作物温度信号感受与应答的蛋白质机器研究 国家重点研发计划(2020.12-2025.11);主持人种康 

[3] 种子精准设计的分子基础 中国科学院先导A项目(2019.11-2024.10);主持人种康 

 [4] 未来作物分子设计 国家自然科学基金科学中心项目(2018.01-2022.12);主持人种康

[5] “水稻产量相关基因克隆与功能研究 科技部十三五重点研发计划(2016.07-2020.12);主持人种康 

研究论文(注*为通讯作者,§为共同第一作者):

2021

Luo W, Huan Q, Xu YY, Qian WF, Chong K*, Zhang JY*. 2021. Integrated global analysis reveals a vitamin E-vitamin K1 sub-network, downstream of COLD1, underlying rice chilling tolerance divergence. Cell Reports, 36(3):58-76.

Yang WS, Wu K, Wang B, Liu HH, Guo SY, Guo XY, Luo W, Sun SY, Ouyang YD, Fu XD, Chong K, Zhang QF*, Xu YY*. 2021. The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice. Molecular Plant, 14(10):1699-1713.

Li ZT, Wang B, Zhang ZY, Luo W, Tang YY, Niu YD, Chong K, Xu YY*. 2021. OsGRF6 interacts with SLR1 to regulate OsGA2ox1 expression for coordinating chilling tolerance and growth in rice. Journal of Plant Physiology, 260:153406.

Xu SJ, Dong Q, Deng M, Lin DX, Xiao J, Cheng PL, Xing LJ, Niu YD, Gao CX, Zhang WH, Xu YY, Chong K*. 2021. A vernalization-induced long non-coding RNA VAS together with transcription factor TaRF2b activates TaVRN1 for flowering in hexaploid wheat. Molecular Plant, 14(9):1525-1538.

Xia CX, Gong YS, Chong K, Xu YY*.2021. Phosphatase OsPP2C27 directly dephosphorylates OsMAPK3 and OsbHLH002 to negatively regulate cold tolerance in rice. Plant Cell and Environment, 44(2):491-505.

2020

Ge Q*, Zhang YY*, Xu YY, Bai MY, Luo W, Wang B, Niu YD, Zhao Y, Li SS, Weng YX, Wang ZY, Qian Q, Chong K*. 2020. Cyclophilin OsCYP20-2 with a novel variant integrates defense and cell elongation for chilling response in rice. New Phytologist, 225:2453–2467.

Tang YY, Gao CC, Gao Y, Yang Y, Shi BY, Yu JL, Lyu C, Sun BF, Wang HL, Xu YY, Yang YG*, Chong K*. 2020. OsNSUN2-mediated 5-methylcytidine mRNA modification enhances rice adaptation to high-temperature. Developmental Cell, 53(3):272-286.

Ge Q, Tang YY, Luo W, Zhang JY, Chong K, Xu YY*. 2020. A cyclophilin OsCYP20–2 interacts withOsSYF2 to regulate grain length by pre-mRNAsplicing. Rice, 13(1):64-74.

2019

Xu SJ, Xiao J, Yin F, Guo XY, Xing LJ, Xu YY, Chong K*. 2019. The protein modifications of O-GlcNAcylation and phosphorylation mediate vernalization response for flowering in winter wheat. Plant Physiology, 180(3):1436-1449.

Zhang JY*, Li XM*, Lin HX, Chong K*. 2019.Crop improvement through temperature resilience. Annual Review of Plant Biology, 70:753-780.

Zhang DJ, Guo XY, Xu YY, Li H, Ma L, Yao XF, Weng YX, Guo Y, Liu CM, Chong K*. 2019. OsCIPK7 pointmutation leads to conformation and kinaseactivity change for sensing cold response. Journal of Integrative Plant Biology, 61(12):1194-1200.

2018

Xing LJ§, Liu Y§, Xu SJ, Xiao J, Wang B, Deng HW, Lu Z, Xu YY, Chong K*. 2018. Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering. EMBO J., 37: e98115.

Xu SJ, Chong K*. 2018, Remembering winter through vernalisation. Nature Plants, 4: 997-1009

Chen LP, Zhao Y, Xu SJ, Zhang ZY, Xu YY, Zhang JY, Chong K*. 2018. OsMADS57 together with OsTB1 coordinates transcription of its target OsWRKY94 and D14 to switch its organogenesis to defense for cold adaptation in rice. New Phytologist. 218: 219-231.

2017

Zhang ZY, Li JH, Li F, Liu HH, Yang WS, Chong K and Xu YY. 2017. OsMAPK3 phosphorylates OsbHLH002/OsICE1 and inhibits its ubiquitination to activate OsTPP1 and enhances rice chilling tolerance. Developmental Cell, 43:731743.

Guo XY, Xu SJ, Chong K2017. Cold signal shuttles from membrane to nucleus. Molecular Cell, 66:7-8.

2016

Zhang JY, Luo W, Zhao Y, Xu YY, Song SH, Chong K2016. Comparative metabolomic analysis reveals a reactive oxygen species-dominated dynamic model underlying chilling environment adaptation and tolerance in rice. New Phytologist, 211: 1295-1310. 

2015

Ma Y*, Dai XY*, Xu YY*, Luo W*, Zheng XM, Zeng DL, Pan YJ, Lin XL, Liu HH, Zhang DJ, Xiao J, Guo XY, Xu SJ, Niu YD, Jin JB, Zhang H, Xu X, Li LG, Wang W, Qian Q, Ge S, Chong K2015COLD1 confers chilling tolerance in rice. Cell, 160: 1209-1221(*These authors contributed equally to this Work). 

Wang LChong K2015. The essential role of cytokin in signaling in root apical meristem formation during somatic embryogenesis. Frontiers in Plant Science, 6: 1196-1200.

2014

Xiao J, Xu SJ, Li CH, Xu YY, Xing LJ, Niu YD Huan Q, Tang Y, Zhao CP, Wagner D, Gao CX, Chong K2014O-GlcNAc-mediated interaction between VER2 and TaGRP2 elicits TaVRN1 mRNA accumulation during vernalization in winter wheat. Nature Communications, 5: 4572. 

Chong K and Xu ZH. 2014. Investment in plant research and development bears fruit in China. Plant Cell Reports, 33: 541-550. 

Liu HH, Ma Y, Chen N, Guo SY, Liu HL, Guo XY, Chong K, Xu YY*. 2014. Overexpression of stress-inducible OsBURP16, the β subunit of polygalacturonase 1, decreases pectin content and cell adhesion and increases abiotic stress sensitivity in rice. Plant Cell and Environment,  37: 1144–1158. 

Liu HH, Guo SY, Xu YY, Li CH, Zhang ZY, Zhang DJ, Xu SJ, Zhang C, Chong K*. 2014. OsmiR396d-regulated OsGRFs Function in Floral Organogenesis in Rice through Binding to their Targets OsJMJ706 and OsCR4. Plant Physiology, 165:160-174. 

2013

Zhang JY, Mao ZW and Chong K2013. A global profiling of uncapped mRNAs under cold stress reveals specific decay patterns and endonucleolytic cleavages in Brachypodiumdistachyon. Genome Biology. 14:R92. 

Zhang YY, Li BB, Xu YY, Li HL, Li SS, Zhang DJ, Mao ZW, Guo SY, Yang CH, Weng YX, and Chong K2013. The Cyclophilin CYP20-2 Modulates the Conformation of BRASSINAZOLE - RESISTANT1, Which Binds the Promoter of FLOWERING LOCUS D to Regulate Flowering in ArabidopsisThe Plant Cell. 25:2504-2521. 

Chen Y, Xu YY, Luo W, Li WX, Chen N, Zhang DJ and Chong K2013. The F-box protein OsFBK12 targets OsSAMS1 for degradation and affects pleiotropic phenotypes including leaf senescence in rice. Plant Physiology. 163:1673-1685. 

Guo SY, Xu YY, Liu HL, Mao ZW, Zhang C, Ma Y, Zhang QR, Meng Z and Chong K2013.  The interaction between OsMADS57 and OsTB1 modulates rice tillering via DWARF14 Nature Communications.4:1566-1574. 

2012

Li CJ, Liu ZJ, Zhang QR, Wang R, Xiao LT, Ma H, Chong K and Xu YY. 2012. SKP1 is involved in abscisic acid signalling to regulate seed germination, stomatal opening and root growth in Arabidopsis thaliana. Plant Cell and Environment, 35, 952–965   

Zhang C, Xu YY, Guo SY, Zhu J, Huan Q, Liu HL, Wang L, Luo GZ, Wang XJ and Chong K2012. Dynamics of brassinosteroid response modulated by negative regulator LIC in rice. PLoS Genetics, 8: e1002686   

2011

Li J, Jiang JF, Qian Q, Xu YY, Zhang C, Xiao J, Du C, Luo W, Zou GX, Chen ML, Huang YQ, Feng YQ, Cheng ZK, Yuan M and Chong K2011. Mutation of rice BC12/GDD1, which encodes a kinesin-like protein that binds to a GA biosynthesis gene promoter, leads to dwarfism with impaired cell elongation. The Plant Cell, 2: 628-640    

Cao H, Guo SY, Xu YY, Jiang K, Jones AM and Chong K2011. Reduced expression of a gene encoding a Golgi localized monosaccharide transporter (OsGMST1) confers hypersensitivity to salt in rice (Oryza sativa). Journal of Experimental Botany, 62:4595-4604    

Chen N, Xu YY, Wang X, Du C, Du JZ, Yuan M, Xu ZH and Chong K2011OsRAN2, essential for mitosis, enhances cold tolerance in rice by promoting export of intranuclear tubulin and maintaining cell division under cold stress. Plant Cell and Environment, 34:52-64    

2010及以前

Li BB, Xu WZ, Xu YY, Zhang YY, Wang T, Bai Y, Han CG, Zhang AM, Xu ZH and Chong K2010. Integrative study on proteomics, molecular physiology and genetics reveals an accumulation of cyclophilin-like protein, TaCYP20-2, leads to increase of Rht protein and dwarf in a novel GA-insensitive mutant (gaid) in wheat. Journal of Proteome Research, 8:4242–4253    

Xing LJ, Li J, Xu YY, Xu ZH and Chong K2009. Phosphorylation modification of wheat lectin VER2 is associated with vernalization-induced O-GlcNAc signaling and intracellular motility. PLoS ONE, 4: e4854    

Wang L, Wang Z, Xu YY, Joo SH, Kim SK, Xue Z, Xu ZH, Wang ZY and Chong K2009. OsGSR1 is involved in cross-talk between gibberellins and brassinosteroids in rice. The Plant Journal, 57: 498-510    

Li D, Wang L, Wang M, Xu YY, Luo W, Liu YJ, Xu ZH, Li J and Chong K2009. Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield. Plant Biotechnology Journal, 7:791–806    

Ma QB, Dai XY, Xu YY, Guo J, Liu YJ, Chen N, Xiao J, Zhang DJ, Xu ZH, Zhang XS and Chong K2009. Enhanced tolerance to chilling stress in OsMYB3R-2 transgenic rice is mediated by alteration in cell cycle and ectopic expression of stress genes. Plant Physiology, 150: 244-256    

Han Y, Cao H, Jiang JF, Xu YY, Du JZ, Wang X, Yuan M, Wang ZY, Xu ZH and Chong K2008. The rice ROOT ARCHITECTURE ASSOCIATED1 binds the proteasome subunit RPT4 and is degraded in a D-box and proteasome dependent manner. Plant Physiology, 148: 843-855   

Wang X, Zhang Y, Ma QB, Zhang ZL, Xue YB, Bao SL and Chong K2007. SKB1-mediated symmetric dimethylation of histone H4R3 controls flowering time in Arabidopsis. The EMBO Journal, 26: 1934-1941    

Zhuang XL, Jiang JF, Li J, Ma QB, Xu YY, Xue YB, Xu ZH and Chong K2006. Overexpression of OsAGAP, an ARF-GAP, interferes with auxin influx, vesicle trafficking and root development. The Plant Journal, 48: 581-591    

Wang X, Xu YY, Han Y, Bao SL, Du J, Yuan M, Xu ZH and Chong K2006. Overexpression of RAN1 in rice and Arabidopsis alters primordial meristem, mitotic progress and sensitivity to auxin. Plant Physiology, 140: 91-101    

Wang Z, Liang Y, Li CJ, Xu YY, Lan LF, Chen CJ, Xu ZH, Xue YB and Chong K2005. Identification of another development-related genes by gene expression profiling with a 10-K cDNA microarray in rice (Oryza sativa L. ). Plant Molecular Biology, 58: 721-737  

Zhuang XL, Xu YY, Chong K, Lan LF, Xue YB and Xu ZH. 2005. OsAGAP, an ARF-GAP from rice, regulates root development dependent mediated by auxin in Arabidopsis. Plant Cell and Environment, 28: 147–156    

Xu YY, Wang XM, Li J, Li JH, Wu JS, John C. Walker, Xu ZH and Chong K2005. Activation of the WUS gene induces ectopic initiation of foral meristems on mature stem surface in Arabidopsis thaliana. Plant Molecular Biology, 57: 773-784   

Ge L, Chen H, Jiang JF, Zhao Y, Xu ML, Xu YY, Tan KH, Xu ZH, and Chong K2004. Overexpression of OsRAA1 causes pleiotropic phenotypes in transgenic rice plants, including altered leaf, flower and root development and root response to gravity. Plant Physiology, 135:1502-1513    

Yong WD, Xu YY, Xu WZ, Li N, Wu JS, Liang TB, Chong K. Xu ZH and Tan KH. 2003. Vernalization-induced flowering in wheat is mediated by a lectin-like gene VER2. Planta, 217:261-270  

出版著作:

[1] 许智宏,种康 主编,2015,植物细胞分化与器官发生,科学出版社。

[2] 邢立静、徐云远、种康2012,植物激素在开花中作用,许智宏、薛红卫主编,植物激素作用的分子机理,上海科技出版社。 

[3] 徐云远、邢立静、张景昱、种康2012,植物对低温的响应,陈晓亚、薛红卫主编,植物生理与分子生物学,高等教育出版社。 

[4] 种康(),瞿礼嘉()2006Dieffenbach, Carl WDveksler, Gabriela S. 主编:PCR技术实验指南。北京:化学工业出版社。 

[5] 种康,王雷,2010Brassinosteroids and G-protein signalingYalovsky S, Baluska F, Jones A主编:Integrated G Proteins Signaling in PlantsSpringer. P.135-154 

专利: 

[1]  、夏昌选、巩燕山、徐云远。OsDBP1蛋白在调控水稻耐冷性中的应用。中国,授权公告日:2020-09-22,专利号:201910107306.X 

[2]  葛强、牛遇达、徐云远OsSYF2蛋白及其编码基因及其在调控水稻粒重中的应用。中国,授权公告日2020-09-22专利号201910107304.0

[3]  高莹、唐永严、徐云远。一种通过抑制OsSDM基因表达提高水稻耐盐性的方法。中国,授权公告日:2020-08-28,专利号:201910103039.9

[4]  葛强、牛遇达、徐云远OsSYF2蛋白及其编码基因及其在调控水稻粒长中的应用。中国,授权公告日:2019-04-16,专利号:201910107378.4

[5]  张泽勇、马启斌、徐云远。蛋白质OsZFP213在调控植物抗逆性中的应用。中国,授权公告日:2014-03-26,专利号:201710982678.8 

[6]  刘栋峰、罗伟、徐云远、唐永严一种植物处理装置。中国,授权公告日:2017-10-20,专利号:201621466511.3 

[7]  刘栋峰、魏福海、徐云远、张泽勇、罗伟一种智能高精度低温水浴箱。中国,授权公告日:2017-03-22,专利号:201620970857.0