姓  名: 王雷
职务/职称: 研究员
联系电话: (86)-010-62836175
电子邮件: wanglei@ibcas.ac.cn
个人网页:
课 题 组: 植物生物钟与发育调控研究组
王雷,男,博士,研究员,博士生导师。

中共党员,1999年,东北师范大学获学士学位; 2002年,吉林农业大学获硕士学位; 2006年,中国科学院植物研究所获博士学位。 2006-2013年,在美国俄亥俄州立大学分子遗传学系从事博士后研究。 20103-20109月,在韩国浦项科技大学作研究访问学者。201311月到植物所工作。 

主要研究方向: 

生物钟分子系统(Circadian molecular system)是生物体为了因应地球自转而产生的昼夜环境周期性的变化,从而进化出的协调细胞内基因表达,及代谢网络调控的分子系统。我们课题组以水稻和拟南芥为模式植物,解析植物生物钟分子系统组成以及对植物生长发育的调控机理,主要包括对开花时间调控、细胞生长以及如何协同细胞内代谢网络方面的分子机理研究。研究核心主要是围绕植物生物钟分子系统如何通过对环境信号的整合而实现对输出系统的控制,以期为提高农作物品质与产量提供时间生物学方面的理论依据和遗传资源。课题组主要研究方向为: 

  1)植物生物钟分子系统的组成解析及关键因子的转录后水平调控; 

  2)水稻生物钟分子系统的表观遗传控制分子机制; 

  3)生物钟分子系统对植物发育的调控及相关分子机理。 

研究论文(*标记为通讯作者) 

2021

Tian WW#, Wang RY#, Bo CP, Yu YJ, Zhang YY, Shin G, Kim W, Wang L*. 2021. SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis. Nucleic Acids Research, doi: org/10.1093/nar/gkab128

2020

Wei H, Wang XL, Xu H, Wang L*.2020. Molecular basis of heading date control in rice. aBIOTECH, 1:219-232

Wei H, Wang XL, He YQ, Xu H, Wang L*. 2020. Clock component OsPRR73 positively regulates rice salt tolerance by modulating OsHKT2;1-mediated sodium homeostasis. The EMBO Journal, 2020.e105086

Li N#, Zhang YY#, He YQ, Wang Y, Wang L*. 2020. Pseudo Response Regulators regulate photoperiodic hypocotyl growth by repressing PIF4/5 transcription. Plant Physiology, 183(2): 686-699 

Wang Y, He YQ, Su C, Zentella R, Sun TP, Wang L*. 2020. Nuclear localized O-fucosyltransferase SPY facilitates PRR5 proteolysis to fine-tune the pace of Arabidopsis circadian clock. Molecular Plant, 3: 446-458 

Wang Y#, Qin YM#,  Li B, Zhang YY, Wang L*. 2020.  Attenuated TOR signaling lengthens circadian period in Arabidopsis. Plant Signaling & Behavior, 2:e1710935 

Kim TS, Wang L, Kim YJ, Somers DE*. 2020. Compensatory mutations in GI and ZTL may modulate temperature compensation in the circadian clock. Plant Physiology, 2: 1130-1141 

2019

Zhang YY, Bo CP, Wang L*. 2019. Novel crosstalks between circadian clock and jasmonic acid pathway finely coordinate the tradeoff among plant growth, senescence and defense. International Journal of Molecular Sciences, 20: 5254 

Li B#, Wang Y#, Zhang YY, Tian WW, Chong K, Jang JC, Wang L*. 2019. PRR5, 7 and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis. Nucleic Acids Research, 10: 5001-5015 

2018

Zhang YY, Wang Y, Wei H, Li N, Tian WW, Chong K, Wang L*. 2018. Circadian evening complex represses jasmonate-induced leaf senescence in Arabidopsis. Mol. Plant, 11, 326-337.

Wang Y, Zhang YY, Wang L*. 2018, Cross regulatory network between circadian clock and leaf senescence is emerging in higher plants. Frontiers in Plant Science, 9: 700.

魏华王岩刘宝辉王雷2018植物生物钟及其调控生长发育的研究进展植物学报, 53: 456-467.

2017

Cha JY, Kim J, Kim TS, Zeng QN, Wang L, Lee SY, Kim WY, Somers DE*. 2017. GIGANTEA acts as a co-chaperone with HSP90 to facilitate maturation of the client protein ZEITLUPE in the Arabidopsis circadian clock. Nat. Commun., 8: 3

2016

Wang L, Chong K. 2016. The essential role of cytokin in signaling in root apical meristem formation during somatic embryogenesis. Frontiers in Plant Science, doi: 10.3389/fpls.2015.01196. 

2015

Jia YB, Tian HY, Li HJ, Yu QQ, Wang L, Friml J, Ding ZJ. 2015. The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development. Journal of Experimental Botany, 4631-4642. 

Choudhary M, Nomura Y, Wang L, Nakagami H, Somers DE. 2015. Quantitative circadian phosphoproteomic analysis of Arabidopsis reveals extensive clock control of key components in physiological, metabolic, and signaling pathways. Molecular & Cellular Proteomics, 14: 2243-2260. 

2013

Wang L, Kim J and Somers D*. 2013. Transcriptional corepressor TOPLESS comlexes with pseudoresponse regulator proteins and histone deacetylase to regulate circadian transcription. Proc. Natl. Acad. Sci. USA, 110(2):761-766. 

Kim Y, Lim J, Yeom M, Kim H, Kim J, Wang L, Somers D and Nam H*. 2013. ELF4 regulates GIGANTEA chromatin access through subnuclear sequestration. Cell Reports, 3:671-677. 

2012

Zhang C, Xu YY, Guo SY, Zhu JY, Huan Q, Liu HH, Wang L, Luo GZ, Wang XJ and Chong K*. 2012. Dynamics of brassinosteroid response modulated by negative regulator LIC in rice. PLoS Genetics, 8(4): e1002686. 

2010及以前

Wang L and Chong K*. Auxin brassinosteroids and G protein signaling. 2010.In Integrated G protein Signaling in Plants. Series of Signaling and Communication in Plants. 2010 page: 135-154 (Book chapter). 

Wang L, Fujiwara S and Somers D*. 2010. PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock. The EMBO Journal, 29(11):1903-1915. 

Li D, Wang L, Wang M, Xu Y, Luo W, Liu Y, Xu Z, Li J and Chong K*. 2009. Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield. Plant Biotechnology Journal, 7:791806.  

Wang L, Xu Y, Zhang C Ma QB, Kim J, Xu ZH and Chong K*. 2008. OsLIC, a novel CCCH-type zinc finger protein with transcription activation, mediates rice architecture via brassinosteroids signaling. PLoS One. 3(10):e3521. 

Fujiwara S, Wang L, Han L, Suh SS, Salomé P, McClung R and Somers D*.  2008. Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins. Journal of Biological Chemistry, 283(34):23073-83. (Co-first author, cover story). 

Wang L, Xu YY, Li J, Powell R, Xu ZH and Chong K*. 2007. Transgenic rice plants ectopically expressing AtBAK1 are semi-dwarfed and hypersensitive to 24-epibrassinolide. Journal of Plant Physiology, 164 (5):655-64.  

Liu KM, Wang L, XuYY, Chen N, Ma QB, Li F and Chong K*. 2007. Overexpression of OsCOIN, a putative cold inducible zinc finger protein, increased tolerance to chilling, salt and drought, and enhanced proline level in rice. Planta, 226(4):1007-16. 

Wang L, Xu YY, Ma QB, Li D, Xu ZH and Chong K*. 2006. Heterotrimeric G protein alpha subunit is involved in rice brassinosteroid response. Cell Research, 16(12):916-922. 

Wang ZY*, Wang QM, Chong K, Wang FR, Wang L, Bai MY and Jia CG. 2006. The brassinosteroid signal transduction pathway. Cell Research, 16(5): 427-34.