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杨文强


职务/职称: 研究员
联系电话: 010-62836945
电子邮件: wqyang@ibcas.ac.cn
个人网页:
课 题 组: 光合作用代谢调控机制研究组

杨文强,男,博士,研究员,博士生导师。

197811月出生于黑龙江省海林市。2000年和2003年在东北农业大学分别获学士和硕士学位,2008年在中国科学院遗传与发育生物学研究所获博士学位。20092月至20171月在美国斯坦福卡内基研究所植物生物学系从事博士后研究和研究助理工作。期间于20093月至5月在美国科罗拉多再生能源国家实验室(NREL)访问研究。20172月到中国科学院植物研究所工作。入选中组部第十三批"青年千人计划"。

主要研究方向:

光合作用是世界上最重要的化学反应(1988年诺贝尔奖颁奖词),人类的衣食住行归根结底都离不开光合作用。莱茵衣藻(Chlamydomonas reinhardtii)是一种单细胞真核绿藻,被称为光合绿色酵母。我们实验室利用衣藻为模式,运用当前多学科先进技术结合获得的大量遗传材料,研究以下科学问题:

1 光合作用新的调控机制。衣藻基因组测序发现597个在光合生物中有同源,而非光合生物中不存在的蛋白,这些蛋白被命名为GreenCut,且绝大部分蛋白的功能是未知的。试图剖析这些蛋白可能在光合作用过程中发挥新的不为所知的功能;

2 光合作用与碳代谢互作网络。光合作用形成的磷酸丙糖的去向直接决定了有机碳的分配,系统的研究这些参与碳代谢网络中酶类,如淀粉酶、磷酸果糖激酶与光合作用的相互作用机制,试图探讨光合作用和这些重要碳代谢网络的互作关系;

3 黑暗代谢对光合作用的调控和乙酸转运代谢机制。光合生物有一半时间是在黑暗中度过的。黑暗代谢拥有与光合作用完全不同的代谢和调控机制。黑暗代谢对光合作用的恢复有很重要的调节作用,试图阐明黑暗代谢机制及其对光合作用的调控机制。同时,衣藻可以利用乙酸为唯一碳源进行黑暗异养生长,试图阐明乙酸转运和代谢的机制;

4 厌氧代谢调控新机理及氧气信号感知。生活在黑暗土壤中的衣藻面临缺氧和厌氧的胁迫,长期进化使衣藻获得独特的厌氧代谢及调控机制。厘清这些机制对于植物涝害研究有一定的理论意义。同时,缺氧和厌氧的感知一直是困扰人们的一大难题。利用已经获得的遗传材料,试图揭示衣藻厌氧代谢调控、生物制氢新机制以及衣藻是如何感知氧气信号的;

5 氧化还原平衡及调控。目前,在衣藻中没有发现完整的植物激素介导的信号转导通路,但是衣藻中诸如铁氧、硫氧、红氧、黄氧、铜氧、钙氧、谷氧还蛋白等众多氧化还原蛋白介导的氧化还原平衡在衣藻生长、发育过程中有重要的调节作用。利用已经获得的遗传材料,试图研究这些氧化还原蛋白的功能及其对在氧化还原平衡调控中的作用。

 

研究论文(*标记为通讯作者)

Peer Reviewed Articles

1.       Mark Heinnickel, Rick Kim, Tyler M Wittkopp, Wenqiang Yang, Karim Walters, Stephen Herbert, Arthur R Grossman. (2016). Tetratricopeptide repeat protein protects photosystem I from oxidative disruption during assembly. PNAS. 113(10): 2774-2779

2.         Wenqiang Yang*,#, Tyler M Wittkopp#, Xiaobo Li, Jaruswan Warakanont, Alexandra Dubini, Rick Kim, Claudia Catalanotti, Eva C M Nowack, Munevver Aksoy, Sarah D’Adamo, Luke Mackinder, Dudley Page, Mark Heinnickel, Xenie Johnson, Jean Alric, Martin C Jonikas, Christoph Benning, Sabeeha Merchant, Matthew C Posewitz, Arthur R Grossman. (2015). Critical role of Chlamydomonas reinhardtii ferredoxin-5 in maintaining membrane structure and dark metabolism. PNAS. 112(48): 14978-14983 (#Equal Contribution)

3.         Wenqiang Yang*, Claudia Catalanotti, Sarah D’Adamo, Tyler M Wittkopp, Cheryl J Ingram-Smith, Luke Mackinder, Tarryn Miller, Adam L. Heuberger, Graham Peers, Kerry S Smith, Martin C Jonikas, Arthur R Grossman, Matthew C Posewitz. Alternative Acetate Production Pathways in Chlamydomonas reinhardtii during Dark Anoxia and the Dominant Role of Chloroplasts in Fermentative Acetate Production. The Plant Cell. 26(11):4499-4518

4.         Deqiang Duanmu, Nathan C Rockwell, Rachel M Dent, Krishna Niyogi, Wenqiang Yang, Arthur R Grossman, Clark Lagarias. (2013). Retrograde bilin signaling enables Chlamydomonas greening and phototrophic survival. PNAS.110(9):3621-3626

5.         Mark Heinnickel ML, Jean Alric, Tyler M Wittkopp, Wenqiang Yang, Claudia Catalanotti, Rachel Dent, Krishina Niyogi, Francis-Andrew Wollman, Arthur R Grossman. (2013).Novel Thylakoid Membrane GreenCut Protein CPLD38 Impacts Accumulation of the Cytochrome b6f Complex and Associated Regulatory Processes. J Biol Chem. 288(10):7024-7036

6.         Claudia Catalanotti, Alexandra Dubini, Venkataramanan Subramanian, Wenqiang Yang, Leonardo Magneschi, Florence Mus, Michael Seibert, Matthew C Posewitz, Arthur R Grossman. (2012). Altered Fermentative Metabolism in Chlamydomonas reinhardtii Mutants Lacking Pyruvate Formate Lyase and both Pyruvate Formate Lyase and Alcohol Dehydrogenase. The Plant Cell. 24:692-707

7.         Leonardo Magneschi, Claudia Catalanotti, Alexandra Dubini, Wenqiang Yang, Matthew C Posewitz, Michael Seibert, Pierdomenico Perata, Arthur R Grossman. (2012). A Mutant in the ADH1 Gene of Chlamydomonas reinhardtii Elicits Metabolic Restructuring during Anaerobiosis. Plant Physiology.158(3):1293-1305

8.         Jonathan E. Meuser, Sarah D’Adamo, Robert E Jinkerson, Florence Mus, Wenqiang Yang, Maria L Ghirardi, Michael Seibert, Arthur R Grossman, Matthew CPosewitz. (2011). Genetic Disruption of both Chlamydomonas reinhardtii [FeFe]-Hydrogenases: Insight into the Role of HYDA2 in H2 Production. Biochem Biophys Res Commun. 417(2):704-709

9.      David Gonzalez-Ballester, Wirulda Pootakham, Florence Mus, Wenqiang Yang, Claudia Catalanotti, Leonardo Magneschi, Jose J. Higuera, Amaury de Montaigu, Matthew Prior, Aurora Galván, Emilio Fernandez, Arthur R Grossman. (2011). Reverse Genetics in Chlamydomonas: A Moderate Throughput Platform for Isolating Insertional Mutants. Plant Methods.7:24. doi:10.1186/1746-4811-7-24

10.      Wenying Xu, Rendong Yang, Meina Li, Zhuo Xing, Wenqiang Yang, Guang Chen, Han Guo, Xiaojie Gong, Zhou Du, Zhenhai Zhang, Xingming Hu, Dong Wang, Qian Qian, Tai Wang, Zhen Su, Yongbiao Xue. (2011). Transcriptome Phase Distribution Analysis Reveals Diurnal Regulated Biological Processes and Key Pathways in Rice Flag Leaves and Seedling Leaves. PLoS One. 6(3): e17613

11.      Wenqiang Yang, Ying Lai, Meina Li,Wenying Xu,YongbiaoXue. (2008). A Novel C2-domain-Containing Phospholipid Binding Protein, OsPBP1, Is Involved in Pollen Fertility in Rice (Oryza sativa L.). Molecular Plant. 1: 770-785

12.      Wenqiang Yang, Zhaosheng Kong,Edith Omo-Ikerodah, Wenying Xu,Yongbiao Xue.(2008). A Calcineurin B-Like Interacting Protein Kinase OsCIPK23 Functions in Pollination and Drought Stress Responses in Rice. Journal of Genetics and Genomics.35:531-543

13.      Meina Li, Wenying Xu, Wenqiang Yang, Zhaosheng Kong,Yongbiao Xue. (2007). Genome-Wide Gene Expression Profiling Reveals Conserved and Novel Molecular Functions of the Stigma in Rice (Oryza sativa L.). Plant Physiology.144:1797-1812

14.      Zhaosheng Kong, Meina Li, Wenqiang Yang, Wenying Xu,Yongbiao Xue. (2006). A Novel Nuclear-Localized CCCH-type Zinc Finger Protein, OsDOS, Is Involved in Delaying Leaf Senescence in Rice (Oryza sativa L.). Plant Physiology. 141: 1376–1388

Reviews and Book Chapters

1.       Tyler M Wittkopp, Shai Saroussi, Wenqiang Yang, Arthur R Grossman. (2015). Chapter 11: The GreenCut - a tool for understanding the functions and relationships of proteins conserved in green lineage organisms. Horizon: Chloroplasts: Current Research and Applications

2.       Wenqiang Yang*, Claudia Catalanotti, Tyler M Wittkopp Matthew C Posewitz, Arthur R Grossman. (2014). Algae after dark: mechanisms to cope with anoxic/hypoxic conditions. Coming of age of Chlamydomonas as a model alga. Plant Journal 82(3):481-503

3.       Wenqiang Yang*, Claudia Catalanotti, Matthew C Posewitz, Jean Alric, Arthur R Grossman. (2014). Insight into Algal Fermentation Metabolism. Springer: Low Oxygen Stress in Plants.

4.       Claudia Catalanotti, Wenqiang Yang, Matthew C Posewitz, Arthur R Grossman. Fermentation metabolism and its evolution in algae. Frontiers in Plant Science. doi: 10.3389/fpls.2013.00150

5.       Arthur R Grossman, Claudia Catalanotti, Wenqiang Yang, Alexandra Dubini, Leonardo Magneschi, Venkataramanan Subramanian, Matthew C Posewitz, Michael Seibert. (2011). Multiple Facets of Anoxic Metabolism and Hydrogen Production in the Unicellular Green Alga Chlamydomonas reinhardtii. New Phytologist. 190(2): 279-88


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